Welcome to the Skardal Biofabrication Lab

The Skardal Biofabrication Lab:

Our research program focuses on the design and implementation of extracellular matrix-inspired hydrogel biomaterials for the biofabrication of tissue and tumor organoids, organ-on-a-chip systems, and cancer-on-a-chip systems for drug screening, disease modeling, and personalized medicine. Our team’s work has broad applicability across tissue types and diseases but has focused primarily in development of cancer models and recently neural models. Our biomaterial systems are largely hyaluronic acid-based with additional custom ECM component addons, synthetically modified in the lab. These are often combined with microfluidic devices for fluid handling capabilities. In particular, we have a significant interest in patient biospecimen-derived models that can facilitate and improve current precision medicine and precision oncology efforts in the clinic.