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Skardal Lab Publications

Peer Reviewed Journal Articles:

2019

50. Aleman J, George SK, Devarasetty M, Herberg S, Porada CD,* Skardal A,* and Almeida-Porada G.* Deconstructed microfluidic bone marrow on-a-chip to study normal and malignant hemopoietic cell–niche interactions. Small. In press. (*corresponding authors).

49. Clark C, Aleman J, Mutkus L, and Skardal A. A mechanically robust thixotropic collagen and hyaluronic acid bioink supplemented with gelatin nanoparticles. Bioprinting. In press.

48. Murphy SV, Skardal A, Nelson RA Jr, Sunnon K, Reid T, Clouse C, Kock ND, Jackson J, Soker S, and Atala A. Amnion membrane hydrogel and amnion membrane powder accelerate wound healing in a full thickness porcine skin wound model. Stem Cells Translational Medicine. 2019. Jul 21.

47. Albanna M, Binder KW, Murphy SV, Kim J, Qasem SA, Zhao W, Tan J, El-Amin IB, Dice DD, Marco J, Green J, Xu T, Skardal A, Holmes JH, Jackson JD, Atala A, and Yoo JJ. In situ bioprinting of autologous skin cells accelerates wound healing of extensive excisional full-thickness wounds. Scientific Reports. 2019. Feb; 9(1): 1856.

46. Mazzocchi A, Devarasetty M, Petty WJ, Marini F, Miller L, Kucera G, Skardal A, and Soker S. Pleural effusion aspirate for use in 3D disease modeling and chemotherapy screening. ACS Biomaterials Science and Engineering. 2019. 5(4): 1937-1943.

45. Forsythe SD, Mehta N, Devarasetty M, Sivakumar H, Gmeiner W, Soker S, Votanopoulos K, and Skardal A. Colorectal cancer tumor organoids for screening of anti-proliferative and targeted chemotherapy agents in vitro. Annals of Biomedical Engineering. 2019. Apr 24.

44. Mazzocchi A, Soker S, Skardal A. 3D Bioprinting for High-Throughput Screening: Drug Screening, Disease Modeling, and Precision Medicine Applications. Applied Physics Reviews. 2019. Feb 6.

43. Votanopoulos KI, Mazzocchi A, Sivakumar H, Forsythe SD, Aleman J, Levine E, and Skardal A. Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study. Annals of Surgical Oncology. 2019. Jan; 26(1): 139-147.

42. Aleman J and Skardal A. A multi-site metastasis-on-a-chip fluidic device for assessing metastatic preference of tumor cells. Biotechnology and Bioengineering. 2019. Apr; 116(4): 936-944.

2018

41. Skardal A. Perspective: “Universal” bioink technology for advancing extrusion bioprinting-based biomanufacturing. Bioprinting. 2018. June. 10: e00026.

40. Mazzocchi A, Devarasetty M, Huntwork RC, Soker A, and Skardal A. Optimization of Collagen Type I-Hyaluronan Hybrid Bioink for 3D Bioprinted Liver Microenvironments. Biofabrication. 2018. Oct. 30; 11(1):015003.

39. Serban MA and Skardal A. Hyaluronan chemistries for three-dimensional matrix applications. Matrix Biology. 2018 Feb 10.

38. Votanopoulos KI, Shen P, Skardal A, Levine EA. Peritoneal metastases from appendiceal cancer. 2018. Jul. 27(3). 551-561.

37. Forsythe S, Devarasetty M, Shupe T, Bishop CE, Soker S, Atala A, and Skardal A. Toxicity testing of FDA-recalled drugs in 3D liver and cardiac organoids. Frontiers in Public Health. 2018. April 16. 6. 103.

36. Devarasetty M, Mazzocchi A, and Skardal A. Application of organoids in drug development and precision medicine. Biodrugs. 2018. Feb. 32(1). 53-68.

35. Mazzocchi AR, Votanopoulos KI, and Skardal A. Personalizing cancer treatments empirically in the laboratory: Patient-specific tumor organoids for optimizing precision medicine. Current Stem Cell Reports. 2018. Feb 13. 8(1). 2886.

34. Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR. Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor. Nature Communications. 2018. Mar 12. 9(1). 1037.

33. Mazzocchi AR, Rajan SAP, Votanopoulos KI, Hall AR, and Skardal A. In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening. Scientific Reports. 2018. Feb 13. 8(1). 2886.

32. Devarasetty M, Mazzocchi AR, and Skardal A. Application of organoids in drug development and precision medicine. BioDrugs. 2018. Feb. 32(1). 53-68.

2017

31. Murphy SV, Skardal A, Song J, Sutton K, Haug R, Mack DL, Jackson J, Soker S, and Atala A. Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-thickness Wound Healing. Stem Cells Translational Medicine.  2017. Nov. 6(11). 2020-2032.

30. Zhang Y, Yi H, Forsythe S, and Skardal A. Tissue-Specific Extracellular Matrix Promotes Myogenic Differentiation of Human Muscle Progenitor Cells on Gelatin and Heparin Conjugated Alginate Hydrogels. Acta Biomaterialia. 2017. Oct 15. 62. 222-233.

29. Devarasetty M, Forsythe S, Shupe T, Soker S, Atala A, and Skardal A. Optical tracking and digital quantification of beating behavior in bioengineered human cardiac organoids. Biosensors. 2017. Jun 23. 7(3). E24.

28. Sivakumar H, Strowd R, and Skardal A. Exploration of dynamic elastic modulus changes on glioblastoma cell populations with aberrant EGFR expression as a potential therapeutic intervention using a tunable hyaluronic acid hydrogel platform. Gels. 2017. 3(3). 28.

27. Skardal A, Murphy SV, Devarasetty M, Mead I, Kang HW, Seol YJ, Zhang YS, Shin SR, Zhao L, Aleman J, Hall AR, Shupe TD, Kleensang A, Dokmeci MR, Lee SJ, Jackson J, Yoo JJ, Hartung T, Khademhosseini, Soker S, Bishop CE, and Atala A. Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Scientific Reports. 2017 Aug 17. 7(1). 8837.

26. Devarasetty M, Wang E, Soker S, and Skardal A. Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy. Biofabrication. June 7. 9(2). 021002.
Devarasetty M, Skardal A, Marini F, and Soker S. Bioengineered Submucosal Organoids for In Vitro Modeling of Colorectal Cancer. Tissue Engineering. 2017 Oct. 23 (19-20). 1026-1041.

25. Zhang YS, Aleman J, Shin SR, Kilic T, Kim D, Mousavi Shaegh SA, Massa S, Riahi R, Chae S, Hu N, Avci H, Zhang W, Silvestri A, Sanati Nezhad A, Manbohi A, De Ferrari F, Polini A, Calzone G, Shaikh N, Alerasool P, Budina E, Kang J, Bhise N, Ribas J, Pourmand A, Skardal A, Shupe T, Bishop CE, Dokmeci MR, Atala A, and Khademhosseini A. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Proceedings of the National Academy of Sciences. 2017 Mar 21. 114(12). E2293-E2302.

2016

24. Skardal A, Shupe T, and Atala A. Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Drug Discovery Today. 2016 Sep. 21(9). 1399-411.

23. Skardal A, Devarasetty M, Kang HW, Seol YJ, Forsythe SD, Bishop C, Shupe T, Soker S, Atala A. Bioprinting cellularized constructs using a tissue-specific hydrogel bioink. Journal of Visualized Experiments. 2016. 110. (Corresponding Author).

22. Skardal A, Murphy S, Crowell K, Mack D, Atala A, and Soker S. A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2016. Jun 28. (Corresponding Author).

21. Skardal A, Devarasetty M, Forsythe SD, Atala A, and Soker S. A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening. Biotechnology and Bioengineering. 2016. (Corresponding Author)

2015

20. Skardal A, Devarasetty M, Rodman C, Atala A and Soker S. Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Annals of Biomedical Engineering. 2015.
19. Skardal A, Devarasetty M, Kang HK, Mead I, Bishop C, Shupe T, Lee SJ, Jackson J, Yoo J, Soker S, and Atala A. “A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Acta Biomaterialia. 2015. (Corresponding Author)
18. Deegan DB, Zimmerman C, Skardal A, Atala A, Shupe TD. Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology. Journal of Mechanical Behavior of Biomechanical Materials. 2015. 55; 87-103.
17. Skardal A, Devarasetty M, Soker S, and Hall AR. In situ patterned micro 3-D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication. 2015 Sep 10. 7(3), 031001. (Corresponding Author)

2014

16. Skardal A and Atala A. Biomaterials for Integration with 3-D Bioprinting. Invited review for Scaffolds for Regenerative Medicine Special Issue of the Annals of Biomedical Engineering. 2014.

15. Niu G, Choi J, Wang Z, Skardal A, Giegengack M, and Soker S. (2014) Heparin-modified gelatin scaffolds for human corneal endothelial cell transplantation. Biomaterials. 35(13), 4005-14.

2013

13. Murphy S*, Skardal A*, and Atala A. (2013) Evaluation of hydrogels for bioprinting applications. Journal of Biomedical Materials Research. 101(1), 272-84. (*These authors contributed equally.)
12. Skardal A, Mack D, Atala A and Soker S. (2013) Reduced substrate elasticity induces a mobile phenotype and recovers therapeutic potential of amniotic fluid-derived stem cells. Journal of Mechanical Behavior of Biomedical Materials. 17, 307-316.
11. Park AH, Hoyt D, Britt D, Chase S, Tansavatdi D, Hunter L, McGill L, Sheng X, Skardal A, and Prestwich GD. (2013) Crosslinked hydrogel and polyester resorbable ventilation tubes in a chinchilla model. The Laryngoscope. 123(4), 1043-8.
10. Markert CD, Guo X, Skardal A, Wang Z, Bharadwaj S, Zhang Y, Bonin K, and Guthold M. (2013) Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine. Journal of Mechanical Behavior or Biomedical Materials. 27, 115-127.

2012

9. Skardal A, Smith L, Bharadwaj S, Atala A, Soker S, and Zhang Y. (2012) Tissue specific synthetic ECM hydrogels for in vitro maintenance of hepatocyte function. Biomaterials.  33(18), 4565-4575.
8. Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, Yoo J, and Soker S. (2012) Bioprinted amniotic fluid-derived stem cells accelerate wound healing of large skin wounds. Stem Cells Translational Medicine. 1(11), 792-802. Featured on journal cover.

2011

7.Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich GD. (2011). A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. Journal of Urology, 186,1684-92.

2010

6. Skardal A, Zhang J, McCoard L, Xu X, Oottamasathien S, and Prestwich GD. (2010). Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. Tissue Engineering Part A, 16(8), 2675-85.
5. Skardal A, Zhang J, and Prestwich GD. (2010). Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates. Biomaterials, 31(24), 6173-81.
4. Skardal A, Zhang J, McCoard L, Oottamasathien S, and Prestwich GD. (2010). Dynamically - crosslinked gold nanoparticle - hyaluronan hydrogels. Advanced Materials, 22, 4736-4740.
3.Skardal A, Sarker S, Nickerson C, and Prestwich GD. (2010). Development of hyaluronan hydrogel-coated microcarriers for generation of three-dimensional tissue models in a rotating wall vessel bioreactor.  Biomaterials, 31(32), 8426-35.

2008

2. Zhang J, Skardal A, and Prestwich GD. (2008). Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery. Biomaterials, 29(34), 4521-4531

1. Liu Y, Skardal A, Shu XZ, and Prestwich GD. (2008). Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury. Journal of Orthopaedic Research, 26(4), 562-569.
 

Book Chapters:

14. Zarembinski T and Skardal A. HyStem®: A Unique Clinical Grade Hydrogel for Present and Future Medical Applications. Invited review chapter for Hydrogels – Smart Materials for Biomedical Applications. Lacramioara Popa, Mihaela Violeta Ghica, and Cristina Dinu-Pirvu. 2019.

13. Ivan C, Skardal A, and Murphy S. “Perinatal Cells and Biomaterials for Wound Healing.” Invited review chapter for Perinatal Stem Cells. Anthony Atala, Kyle Cetrulo, Rouzbeh Taghizadeh, Curtis Cetrulo, and Sean Murphy. 2018.

12. Skardal A, Shupe T, and Atala A. “Body-on-a-chip: Regenerative Medicine for Personalized Medicine” Invited review chapter for Principles of Regenerative Medicine. Anthony Atala, Robert Lanza, James A. Thompson, and Roger Nerem. 2018.

11. Mazzocchi A, Soker S, and Skardal A. “Biofabrication Technologies for Developing In Vitro Tumor Models.” Review chapter for Tumor Organoids. Shay Soker and Aleksander Skardal. 2017.

10. Skardal A, Devarasetty M, Murphy SV, and Atala A. “Integrated Multi-Organ Dynamics.” Invited review chapter for Regenerative Medicine Technology: On-a-chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. Anthony Atala and Sean Murphy. CRC Press. 2017

9. Devarasetty M, Forsythe S, Shupe T, Skardal A, and Soker S. “Body-on-a-Chip.” Invited review chapter for Regenerative Medicine Technology: On-a-chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. Anthony Atala and Sean Murphy. CRC Press. 2017

8. Skardal A. “Liver and liver cancer-on-a-chip.” Invited review chapter for Regenerative Medicine Technology: On-a-chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. Anthony Atala and Sean Murphy. CRC Press. 2017

7. Skardal A. “Biopolymers for in vitro tissue model biofabrication” Invited review chapter for Biopolymers for Medical Applications. CRC Press. 2017.

6. Binder K and Skardal A. “Human Skin Bioprinting: Trajectory and Advances.” Invited review chapter for Skin Tissue Engineering and Regenerative Medicine. Mohammad Albanna and James Holmes. Elsevier. 2016.

5. Skardal A and Atala A. “Bioprinting Essentials of Cell and Protein Viability.” Invited review chapter for 3D Biofabrication for Biomedical and Translational Research.  Anthony Atala and James Yoo, Editors-in-Chief. Elsevier. 2015.

4. Mack D, Skardal A, Soker S, and Atala A. “Using biomaterials for stem cell isolation, expansion and directed-differentiation.” Invited review chapter for Biomaterials and Regenerative Medicine. Peter Ma, Editor-in-Chief. Cambridge University Press. September 2014.

3. Skardal A. “Amniotic fluid stem cells for wound healing.” Invited review chapter for Perinatal Stem Cells: Biology & Clinical Applications.  Anthony Atala, Editor-in-Chief. Springer Science and Business Media. August 2014.

2. Albanna M, Skardal A, and Holmes JH. “Polymers for Skin Tissue Engineering.” Invited review chapter for Encyclopedia of Biomedical Polymers and Polymeric Biomaterials.  Taylor & Francis Group. August 2014.

1. Skardal A. “Extracellular matrix-like hydrogels for applications in regenerative medicine.” Invited review chapter for Hydrogels in Cell-Based Therapies.  Che Connon and Ian W. Hamley, Editors-in-Chief. Royal Society of Chemistry. March 2014.

Books:

1. Tumor Organoids. Edited by Shay Soker and Aleksander Skardal. Springer Nature. 2017

Patents and Patent Applications:

24. Skardal, A and Clark C. Immersion Deposition Methods and Compositions for Use in the Same. US Provisional Patent Application No. 62/715,548.
23. Skardal, A and Clark C. Compositions Including Gelatin Nanoparticles and Methods of Use Thereof. US Provisional Patent Application No. 62/718,662.
22. Skardal, A and Votanopoulos, K. Organoids Related to Immunotherapy and Methods of Preparing and Using the Same. U.S. Provisional Application.
21. Skardal, A and Sivakumar, H. Compositions, Cell Constructs and Methods of Making and Using the Same. U.S. Provisional Application.
20. Skardal A, Porada C, Almeida-Porada G. Niches-On-a-Chip. U.S. Provisional Application.
19. Skardal, A., Shupe, T., and Atala, A. Multi-Organ “Body on a Chip” Apparatus Utilizing a Common Media. U.S. Provisional Application.
18. Skardal, A. Cancer Modeling Platforms and Methods of Using the Same. U.S. PCT Application
17. Skardal, A. Evaluation of Two Novel Colorectal Cancer Modeling Platforms. WFIRM 17-901.
16. Skardal, A. Methods and Apparatus for Modeling Metastasis In Vitro. Patent Application No. 62/236,361 and Application No. 62/241872
15. Skardal, A. Spontaneously Beating Cardiac Organoid Constructs and Integrated Body-on-Chip Apparatus Containing the Same. Patent Application No. 62/236,348
14. Skardal A, and Soker S. Tissue Mimicking Hydrogel Compositions for Biofabrication. Patent Application No. 62/068,218.
13. Murphy S, Skardal A, and Atala A. Amniotic Membrane Powder and Methods of Making. Patent Application No. 14/449,705.
12. Murphy S, Skardal A, and Atala A. Amniotic Membrane Hydrogel and Methods of Making. Patent Application No. 14/449,867.
11. Murphy S, Skardal A, and Atala A. Solubilized Amniotic Membrane (SAM) and Its Use In Wound Healing and Tissue Engineering Constructs. Provisional Patent Application No. 61/698,960.
10. Zhang Y, Atala A, Soker S, and Skardal A. Tissue-Specific Extracellular Matrix With or Without Tissue Protein Components for Cell Culture. Provisional Patent Application No. 61/412,193.
9. Skardal A, Zhang, J, and Prestwich GD. Crosslinked Hydrogels and Methods of Making and Using Thereof. EP Patent 2,523,656. 2012.
8. Skardal A, Zhang, J, and Prestwich GD. Crosslinked Hydrogels and Methods of Making and Using Thereof. Patent application 13/522,032.
7. Prestwich GD, Skardal A, and Zhang J. Hydrogels Crosslinked with Gold Nanoparticles. EP Patent 2,384,439. 2011.
6. Prestwich GD, Skardal A, and Zhang J. Hydrogels Crosslinked with Gold Nanoparticles and Methods of Making and Using Thereof. Provisional patent application 61/148,526, PCT application PCT/US09/68470.
5. Prestwich GD, Skardal A, and Zhang J. Modified Macromolecules and Methods of Making and Using Thereof. EP Patent 2,399,940. 2011.
4. Prestwich GD, Skardal A, and Zhang J. Modified Macromolecules and Methods of Making and Using Thereof. US Patent Application No. 12/764,466. 2010.
3. Prestwich GD, Skardal A, and Zhang J. Tetrahedral Polyethylene Glycol Tetracrylates - Crosslinked Hyaluronan-Gelatin Hydrogels. Provisional patent application submitted.
2. Prestwich GD, Zhang J, and Skardal A. Fall-Apart Composites and Methods of Use Thereof. Provisional patent application 61/051,698.
1. Prestwich GD, Zhang J, and Skardal A. Printable Photocrosslinkable Hydrogels for Tissue Engineering and Tumor Xenografts.  Provisional patent application submitted.

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